Paul Ponath
Principal Scientist Bolt Biotherapeutics
Paul Ponath is a Senior Principal Scientist at Bolt Biotherapeutics with over 15 years of expertise in biotech and biopharmaceutical development across autoimmune, inflammation, and oncology therapeutic areas. As an accomplished immunologist, he specializes in antibody-based immunotherapies with focus on modulation of immune responses. His technical expertise spans cellular and molecular immunology, target discovery, antibody optimization and engineering, and recombinant expression systems. Ponath has extensive experience leading multidisciplinary translational research teams, advancing antibodies from discovery through clinical development while managing IND-enabling activities and regulatory documentation.
Seminars
- Characterizing the immune composition of preclinical tumor models and the therapeutic relevance to patient populations
- Understanding mechanism of action-dependent relationships between antigen density and treatment efficacy demonstrates potential ISAC advantages over conventional antibody-drug conjugates in clinical translation
- Tumor-targeted myeloid activation stimulates both innate and adaptive immune responses transforming immunologically cold tumors into hot microenvironments resulting in more durable responses
