Modeling What Matters: Preclinical Evaluation of T Cell Engagers for Solid Tumors
- Addressing the challenge of modeling solid tumor microenvironment complexity to enable predictive preclinical evaluation of T cell engager therapies
- Presenting a decision-driven model selection framework to inform efficacy, PK/PD, mechanism of action, and safety translation
- Demonstrating how insights from strategically designed, fit-for-purpose models inform clinical development strategies for solid tumor T cell engagers