Modeling Tumor Heterogeneity to Capture Variable Patient Responses in Oncology
- Evaluating inter-patient variability by leveraging diverse preclinical models to predict the range of clinical responses and identify potential non-responders
- Incorporating prior treatment history and resistance mechanisms in models to better reflect real-world patient populations and improve translational relevance
- Designing models that address intra-tumor heterogeneity to ensure reproducible and clinically meaningful preclinical efficacy data