Engineered Myeloma Models Reveal Spatial Tumor–Stroma Dependencies
- Engineered myeloma models (GEMM/CDX) with spatial transcriptomics to resolve tumor microenvironment architecture
- Targeted NSD2 degradation disrupts supportive niches and reprograms myeloma–stroma signaling in situ
- Model-guided framework to rank combinations and de-risk translation for next-gen multiple myeloma therapies