Applying In Vitro Tissue Models to Evaluate Target Expression & Anticipate Safety of Bispecific T Cell Engagers

• Exploring tumor models in vitro to assess target engagement, cytotoxicity, and mechanistic outcomes beyond primary tumor efficacy
• Profiling target expression across tissues to map potential off-tumor effects and guide tissue panel selection
• Alternative in vitro safety models to anticipate potential toxicity liabilities 

Speakers:

Barbara Sennino

Senior Vice President & Head of Early Development

3T Biosciences